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Some other variables not recorded and measurement error may play a role in the observed variability. The accumulation of different kind of errors may be heterogeneous among centers and professionals.

The main sources of errors are: deficient quality in patient record files, errors in diagnostic coding and in recoding from ICPC-2 to ICD-9-MC. Our source of information for prescription cost was the patient electronic files, which records information of printed prescriptions. This is an overestimation of real cost invoiced to the health system for several reasons: a prescription might be printed several times because of technical problems.